Arsenic trioxide, sold under the brand name Trisenox among others, is an inorganic compound and medication. As an industrial chemical, it is used in the manufacture of wood preservatives, pesticides, and glass. As a medication, it is used to treat a type of cancer known as acute promyelocytic leukemia What is arsenic trioxide? Arsenic trioxide is used to treat a cancer of the blood and bone marrow called acute promyelocytic (pro-MYE-loe-SIT-ik) leukemia, or APL. Arsenic trioxide is sometimes given in combination with another medicine called tretinoin. Arsenic trioxide may also be used for other purposes not listed in this medication guide
Results/conclusions: A series of clinical trials with arsenic trioxide has confirmed its benefit in the therapy of APL. Its role in the treatment of other malignancies remains to be determined. Careful attention to the clinical management of patients on arsenic trioxide therapy can significantly lessen the risk of major side effects Arsenic trioxide (Trisenox, ATO) Arsenic trioxide is a chemotherapy drug and is also called Trisenox or ATO. It is a treatment for a type of acute myeloid leukaemia called acute promyelocytic leukaemia (APL) Arsenic Trioxide Microbial Poly-3-Hydroxybutyrate and Related Copolymers. Raveendran Sindhu, Arsenic trioxide loaded... Alkaline Salt Solutions for Acid Gas Removal. Arsenite Solutions. Addition of essentially stoichiometric proportions of... Arsenic. Jennifer K. Saxe, Arsenic is. Arsenic trioxide is the generic name for the trade name drug Trisenox®. In some cases, health care professionals may use the trade name Trisenox® when referring to the generic drug name Arsenic Trioxide. Drug type: Arsenic Trioxide is an anti-cancer (antineoplastic or cytotoxic) chemotherapy drug. This medication is classified as a natural product
Arsenic Trioxide Safety Data Sheet according to Federal Register / Vol. 77, No. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 09/22/2014 Revision date: 12/06/2016 Supersedes: 12/06/2016 Version: 1. Peer-review: Arsenic trioxide can be dissolved in sodium hydroxide, treated to precipitate the sulfide, solidified and deposited in a landfill. Small amt of As2O3 /arsenic trioxide/ in containers can be buried in landfills. (Peer-review conclusions of an IRPTC expert consultation (May 1985) Arsenic trioxide medac is used to treat adults (aged 18 years or over) with acute promyelocytic leukaemia (APL). APL is a rare form of leukaemia (cancer of the white blood cells) caused by a genetic 'translocation' (when there is a swap of genes between two chromosomes)
Arsenic trioxide can be used as a single agent and induces complete remissions with only minimal myelosuppression (1). Investigators in China introduced arsenic trioxide, alone and in combination chemotherapies, as a cancer therapeutic for patients with APL, achieving notable rates of complete remission Description: Arsenic trioxide, an antineoplastic agent, induces apoptosis by causing morphological changes and DNA fragmentation in acute promyelocytic leukemia (APL) cells.It also damages and degrades promyelocytic leukemia (PML)-retinoic acid receptor (RAR)-α fusion gene, a characteristic of APL. Pharmacokinetics 1 : a solid chemical element that is used especially in wood preservatives, alloys, and semiconductors and is extremely toxic in both pure and combined forms — see Chemical Elements Table. 2 : a poisonous trioxide As2O3 or As4O6 of arsenic used especially as an insecticide or weed killer. — called also arsenic trioxide Arsenic(III) oxide. undefined. Synonyms: Arsenous acid, Arsenic trioxide. CAS 1327-53-3. Molecular Weight 197.84. Browse Arsenic(III) oxide and related products at MilliporeSigma In 2018 we built new production line of arsenic trioxide, in 2019 we completed new production of arsenic metal, now we are the main supplier of arsenic metal and arsenic trioxide. We also import lead ore, lead concentrate, tin concentrate, antimony ore and other nonferrous minerals
Arsenic trioxide was embryolethal and teratogenic in rats when administered on gestation day 9 at a dose ~10 times the recommended human daily dose on a mg/m² basis. A related trivalent arsenic, sodium arsenite, produced teratogenicity when administered during gestation in mice at a dose ~5 times the projected human dose on a mg/m² basis and. Arsenic Trioxide Injection is an injectable solution for intravenous administration supplied as 10 mg /10 mL of arsenic trioxide in single-use vials. 4 CONTRAINDICATIONS Arsenic Trioxide Injection is contraindicated in patients who are hypersensitive to arsenic. 5 WARNINGS AND PRECAUTION
ARSENIC TRIOXIDE, as As: METHOD 7901, Issue 2, dated 15 August 1994 - Page 3 of 4 6. Carefully rinse the material on the bottom of the watchglass, and the sides of the beaker into the sample solution with distilled water. Add 6 mL 30% H2O2. 7. Evaporate just to dryness on the steambath. 8. Cool beakers arsenic trioxide: (As) [ ahr´sĕ-nik ] a chemical element, atomic number 33, atomic weight 74.92. (See Appendix 6.) It is toxic by inhalation or ingestion, and carcinogenic (see arsenic poisoning ). In nature it occurs usually as one of its salts; in human environments it is often a pollutant in mining regions, and is used in dyes, household. Arsenic trioxide comes as a solution (liquid) to be injected into a vein by a doctor or nurse in a medical office or clinic. Arsenic trioxide is usually injected over 1 to 2 hours, but it may be injected over as long as 4 hours if side effects are experienced during the infusion. It is usually given once a day for a specific period of time This material contains Arsenic trioxide (listed as Arsenic, inorganic compounds), 100.0%, (CAS# 1327-53-3) which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Part 373. OSHA - Highly Hazardous: None of the chemicals in this product are considered highly hazardous by OSHA
Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of dangerous adverse effects. The enzyme thioredoxin reductase has recently been. Arsenic Trioxide Phebra must be administered intravenously at a dose of 0.15 mg/kg/day, given daily until complete remission is achieved. If complete remission has not occurred by day 60, dosing must be discontinued. Consolidation schedule. Arsenic Trioxide Phebra must be administered intravenously at a dose of 0.15 mg/kg/day, 5 days per week Arsenic trioxide crosses the placenta (Concha 1998). Based on the mechanism of action and findings in animal reproduction studies, arsenic trioxide may cause fetal harm if administered during pregnancy. Arsenic trioxide occurs naturally and toxicity varies between organic and inorganic forms (IOM 2000) Arsenic trioxide Mylan must be diluted with 100 to 250 ml of glucose 50 mg/ml (5%) solution for injection or sodium chloride 9 mg/ml (0.9%) solution for injection immediately after withdrawal from the vial. Arsenic trioxide Mylan must not be mixed with or concomitantly administered in the same intravenous line with other medicinal products Properties. Arsenic trioxide is a white solid. It dissolves in water to make an acidic solution of arsenious acid.It dissolves easily in bases to make arsenites.It reacts with concentrated hydrochloric acid to make arsenic trichloride.It reacts with very strong oxidizing agents to make arsenic pentoxide.It reacts with reducing agents to make arsenic or arsine
Arsenic trioxide, sold under the brand name Trisenox among others, is an inorganic compound and medication. As a medication, it is used to treat a type of cancer known as acute promyelocytic leukemia. For this use it is given by injection into a vein. Arsenic trioxide has the formula As2O3 Arsenic trioxide is the most important commercial compound of arsenic, and the main starting material for arsenic chemistry.It is the highly toxic byproduct of certain kinds of ore processing, for example gold mining diarsenic trioxide. Dioxodiarsoxan [German] [ACD/IUPAC Name] Dioxodiarsoxane [ACD/IUPAC Name] Dioxodiarsoxane [French] [ACD/IUPAC Name] MFCD00003433. Trisenox [Trade name] White arsenic. (99.999%-As) PURATR EM. 1,2-epoxy-3,4-dihyd roxy-1,2,3,4-tetrah ydrobenzo (c)phenant hrene Define arsenic trioxide. arsenic trioxide synonyms, arsenic trioxide pronunciation, arsenic trioxide translation, English dictionary definition of arsenic trioxide. n. A poisonous, white amorphous powder, As2O3, used in insecticides, rat poisons, weed killers, pigments, and preservatives for hides and wood.. Arsenic definition is - a solid chemical element that is used especially in wood preservatives, alloys, and semiconductors and is extremely toxic in both pure and combined forms
Arsenic trioxide (ATO) is an effective cancer therapeutic drug for acute promyelocytic leukemia and has potential anticancer activity against a wide range of solid tumors. ATO exerts its effect mainly through elevated oxidative stress, but the exact molecular mechanism remains elusive. The thioredoxin (Trx) system comprising NADPH, thioredoxin reductase (TrxR), and Trx and the glutathione (GSH. arsenic trioxide, cardiotoxicity. Unnikrishnan et al have reported the occurrence of torsades de pointes in 3 of 19 patients treated with arsenic trioxide. 1 The propensity for arsenic to cause reversible Q-T interval prolongation is well known and has previously been characterized. 2 To minimize the risk of long Q-T-related arrhythmias.
The following 12 files are in this category, out of 12 total. Arsenic trioxide - mechanism of action.png 2,556 × 1,877; 1 MB. Arsenic trioxide with label.JPG 905 × 1,517; 776 KB. Arsenic trioxide'.jpg 1,061 × 1,340; 188 KB. Arsenic trioxide.jpg 542 × 425; 28 KB. Arsenic Trioxide.svg 66 × 68; 6 KB . Lupus animal model has shown that arsenic trioxide (ATO), a treatment of acute promyelocytic leukaemia, could be effective in SLE. This is the first clinical study to determine the safety and efficacy of a short course of intravenous ATO in patients with active SLE. This phase IIa, open-label, dose-escalating study enrolled 11 adult SLE patients with a non-organ threatening disease, clinically. Arsenic trioxide is commonly used for the treatment of APL and providing high remission rates in APL patients. 105 The fact is that although ATO could not demonstrate its therapeutic potential against non-M3 leukemia and solid tumors as a single agent, the combination of ATO with other therapies has shown promising results against different. Arsenic trioxide (ATO)‑induced hepatotoxicity limits the therapeutic effect of acute myelogenous leukemia treatment. Magnesium isoglycyrrhizinate (MgIG) is a natural compound extracted from licorice and a hepatoprotective drug used in liver injury. It exhibits anti‑oxidant, anti‑inflammatory and anti‑apoptotic properties. The aim of the present study was to identify the protective.
Synonyms for arsenic trioxide in Free Thesaurus. Antonyms for arsenic trioxide. 5 synonyms for arsenic trioxide: arsenic, arsenous anhydride, arsenous oxide, ratsbane, white arsenic. What are synonyms for arsenic trioxide Arsenic is a trace element that occurs naturally in very small amounts in the diet. Its exact functions are not known. The estimated adult daily intake of arsenic from a typical diet is 12-50 mcg Arsenic is a ubiquitous and well-proven carcinogenic metal that is widely distributed in air, water, and soil. 1,2 People are exposed to arsenic through inhalation, ingestion, skin contact, and parenteral routes, which can influence health, including cardiovascular and peripheral vascular disease. 3 However, arsenic trioxide (ATO), the main. Arsenic trioxide (ATO) is an active ingredient in traditional Chinese medicine and it has been approved by the United States Food and Drug Administration (FDA) as a first-line antitumor drug against acute promyelocytic leukemia. 4 Furthermore, ATO has also demonstrated excellent antitumor effects on various solid tumors, eg, liver cancer. . ORH-2014 is a novel formulation of arsenic trioxide, developed using a patented process to produce micron-sized drug particles with high surface area and rapid dissolution profile
.On the basis of product type, more than 99% Purity. Arsenic trioxide, the most common arsenic compound in commerce, melts at 312°C and boils at 465°C (ATSDR 2007). In wa-ter, elemental arsenic is insoluble, calcium arsenate and arsenites are sparingly soluble, and arsenic trioxide, arsenic pentoxide, and other arsenicals are soluble. Arsenic pentoxide, potassium arsenite, and th Arsenic trioxide can cause cancer in humans. Other long term effects include: anemia, liver and kidney damage. Chronic exposure to arsenical dust may cause shortness of breath, nausea, chest pains, and garlic odor. Section 4 - First Aid Measures Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and. Both arsenic trioxide and panobinostat prolong the QT interval. Most manufacturers advise avoiding the use of two or more drugs that are associated with QT prolongation. Increasing age, female sex, cardiac disease, and some metabolic disturbances (notably hypokalaemia) predispose to QT prolongation ARSENIC TRIOXIDE reacts vigorously with fluorine at ordinary temperatures [Mellor 9:34 1946-47]. Dissolves in aqueous acids. Incompatible with tannic acid, infusions of cinchona and other vegetable astringent infusions and decoctions, and with iron in solution [Merck]
Giving arsenic trioxide with itraconazole may work better in treating basal cell cancer. This phase II trial studies how well arsenic trioxide works in treating patients with relapsed or refractory acute myeloid leukemia. Drugs used in chemotherapy, such as arsenic trioxide, work in different ways to stop the growth of cancer cells, either by. TY - JOUR. T1 - Arsenic trioxide. AU - Litzow, Mark R. PY - 2008/7/1. Y1 - 2008/7/1. N2 - Background: The ancient drug, arsenic, has remarkable efficacy in the treatment of relapsed acute promyelocytic leukemia (APL) and this success has led to exploration of its use in other malignancies An orally bioavailable capsule formulation of the inorganic toxic compound arsenic trioxide (As2O3), with potential antineoplastic activity. Although the mechanism of action (MoA) of As2O3 is not well understood, upon oral administration of ORH 2014, As2O3 appears to bind to DNA, prevent DNA synthesis, and cause DNA fragmentation, which leads to an induction of apoptosis in proliferating cells. . [ncbi.nlm.nih.gov]  arsenic trioxide induce apoptosis (cell death), which inhibits the process of angiogenesis and related cancerous cell production. 1 Side effects: The chief side effect seen in arsenic trioxide is.
Newly published data from a phase IIa drug trial shows the treatment arsenic trioxide (ATO) showed positive results for people with lupus. Initial findings also show encouraging efficacy results for the treatment of refractory lupus (lupus that persists or worsens despite conventional treatment) ARSENIC TRIOXIDE ARSENIC TRIOXIDE Extra Pure Arsenic(III) oxide, Arsenous acid, Diarsenic trioxide; Article No. 01530. Grade Extra Pure. Purity 98%. CAS No. 1327-53-3. Molecular Formula As 2 O 3. Molecular Weight 197.84. H.S. Code. Arsenic, an ancient drug used in traditional Chinese medicine, has attracted worldwide interest because it shows substantial anticancer activity in patients with acute promyelocytic leukemia (APL). Arsenic trioxide (As2O3) exerts its therapeutic effect by promoting degradation of an oncogenic protein that drives the growth of APL cells, PML-RARα (a fusion protein containing sequences from the. Arsenic trioxide was also shown to be effective as monotherapy, and in due course received regulatory approval for treatment of relapsed disease (in September, 2000, in the USA and in October, 2001, in the European Union). Initial non-randomised studies suggested that the combination of ATRA and arsenic trioxide resulted in a high cure rate
Arsenic trioxide is known to modulate multiple signal transduction pathways, including inhibition of telomerase activity, induction of reactive oxygen species release, and inhibition of survival pathways involving extracellular signal regulated kinase, Akt, calcium signaling and NF-κB activities [14-17,28] diarsenic trioxide. Dioxodiarsoxan [German] [ACD/IUPAC Name] Dioxodiarsoxane [ACD/IUPAC Name] Dioxodiarsoxane [French] [ACD/IUPAC Name] MFCD00003433. Trisenox [Trade name] White arsenic. (99.999%-As) PURATR EM. 1,2-epoxy-3,4-dihyd roxy-1,2,3,4-tetrah ydrobenzo (c)phenant hrene Introduction. Even though arsenic compounds are well-known as a poison, they have found several beneficial applications in medicine including cancer therapy. 1-3 For instance, in 2000 arsenic trioxide (As 2 O 3) was approved by the U.S. Food and Drug Administration (FDA) as a drug for treatment of acute promyelocytic leukemia (APL) 4 and since 2016 the drug has also been approved by the. Arsenic trioxide is used to treat a cancer of the blood and bone marrow called acute promyelocytic (pro-MYE-loe-SIT-ik) leukemia, or APL. Arsenic trioxide is sometimes given in combination with. Arsenic trioxide may cause fetal harm when administered during pregnancy, based on its mechanism of action and data from animal studies. Females of reproductive potential should avoid becoming pregnant during arsenic trioxide therapy. Discuss the potential hazard to the fetus if arsenic trioxide is used during pregnancy or if a patient becomes.
Introduction. In 2000 arsenic trioxide (ATO) was approved by the FDA (US Food and Drug Administration) as a drug for treating refractory or relapsed acute promyelocytic leukaemia (APL) 1 and since 2016 it is also approved by the EMA (European Medicines Agency) for treating newly diagnosed APL. 2 Expending the medical use of ATO is challenging and often fails due to its high toxicity—only 15. Arsenic trioxide increased expression of precursor forms of caspase 2 and caspase 3, along with activated (cleaved) forms of caspase 1. A control for the amount of protein loaded, stained with. Pilot studies of arsenic trioxide as a single agent have shown encouraging results, which were particularly favorable for patients with low-to-intermediate-risk disease. 22,24 Other trials have. Arsenic trioxide (ATO), one of the oldest remedies used in traditional medicine, was recently rediscovered as an anticancer drug and approved for treatment of relapsed acute promyelocytic leukemia. However, its activity against nonhematologic cancers is rather limited so far. Here, we show that inhibition of ATO-mediated EGF receptor (EGFR) activation can be used to potently sensitize diverse.
Arsenic trioxide is available for home use in ant baits. Potential arsenic toxicity from unintentional pediatric ingestion is not well studied. The goal of this study is to describe the clinical course and urinary arsenic concentrations of children who ingested ant bait containing arsenic trioxide (0.46%). Methods Translational Relevance. Arsenic trioxide (As 2 O 3) is a highly effective therapy for acute promyelocytic leukemia and has antitumor activity in preclinical models of solid tumors; however, clinical trials of As 2 O 3 in several solid tumors reveal a narrow therapeutic window that limits wider application. Nanoscale drug carriers have increased the therapeutic index of several cytotoxic. In cells treated with arsenic trioxide (6 μM) for 48 h, about 40% of the water-soluble arsenic present was found to exist in the metallothionein (MT) protein component. MTs can bind to metal elements, thereby protecting cells from arsenic toxicity. Further stud-ies of the interactions between arsenic trioxide and MT subtypes, with dierent dose
Arsenic trioxide (Trisenox) has been approved by the FDA in combination with the all-trans retinoic acid (ATRA) agent tretinoin for the treatment of adults with newly-diagnosed low-risk acute promyelocytic leukemia (APL) with the t (15;17) translocation or PML-RARA gene expression. According to Teva Pharmaceuticals, the company developing the. Crude arsenic trioxide is relatively insoluble but may be converted to more soluble derivatives such as arsenious acid or sodium arsenite in some preparations. EPIDEMIOLOGY Arsenic trioxide is the major source of occupational exposure to arsenic compounds, especially from the processing of copper, gold and lead ores A prospective open-label phase 2 study will be designed to assess the efficacy of oral arsenic trioxide plus azacitidine in preventing relapses in patients with NPM1-mutant AML. After screening and eligibility assessment, patients will receive treatment with oral arsenic trioxide plus azacitidine for 12 months Arsenic trioxide initiates degradation of PML (or PML-RARA) by promoting PML aggregation into subnuclear domains implicated in senescence and apoptosis. Several studies in humans and mice have shown that ATRA and arsenic trioxide dramatically synergize for eradication of APL, presumably because this therapeuti